Endocrine Abstracts

Background: Despite adequate glucocorticoid (GC) and mineralocorticoid (MC) replacement therapy, primary adrenal insufficiency (AI) is associated with an increased mortality, mainly due to cardiovascular disease. The role of MC replacement is not known. Therefore we assessed whether renin concentrations during routine GC and MC substitution therapy are associated with cardiac function and morphology.Methods: 17 patients with AI underwent magnetic resonan...

Background: Human chronotypes can be defined as the natural preference for specific wake and sleep times, as measured by the start and end of sleep on days without temporal restrictions. They are a consequence of the circadian clock individual periods. Cortisol is a key mediator for the rhythmic expression of circadian signals in almost all tissues. Physiological timing of cortisol levels is strictly regulated by the hypothalamic-pituitary-adrenal (HPA) axis. Diseases affectin...